Stem Cells in Dentistry: A Boon to Oral & Maxillofacial Surgery

نویسندگان

  • Saba Majid
  • Ramesh Ram Fry
  • Samta Goyal
  • Jatinder Pal Singh Chawla
چکیده

Objectives: Here, a brief overview of the state-of-the-science in dentistry, oromaxillofacial diseases especially oral cancers is given and discussion of possible implications of the stem cell hypothesis to the treatment and management part is focussed. Material and Methods: The authors used „„PUBMED‟‟ to find relevant literature written in English and published from the discovery of stem cells until today. A combination of keywords was used as the search terms e.g., “stem cells”, „„tissue engineering‟‟, „„approaches‟‟, „„strategies‟‟ „„dentistry‟‟, „„regenerative dentistry‟‟, „„oral surgery‟‟, „„oral & maxillofacial surgery‟‟, „„craniofacial stem cells‟‟ and „„head & neck cancer stem cells”. Results: Stem cells have self-renewal abilities and are capable of differentiating into multiple cell lineages; hence a promising candidate for cell-based tissue engineering. Adult Stem cells derived from bone marrow (BMSCs) are most commonly used for bone regeneration purposes. Stem cells can be useful in the regeneration of bone and to correct large craniofacial defects due to cyst enucleation, tumor resection, and trauma. The closure of a bone defect is commonly carried out with the transfer of tissue, which have disadvantages like, not able to restore the unique function of the lost part, donor site morbidity, accompanied by scarring, infection and loss of function. Stem cells in oromaxillofacial region can replace this technique by having no such disadvantage. Conclusions: The future dentistry will be more of regenerative based, where patients own cells can be used to treat diseases. Stem cell therapy has got a paramount role as a future treatment modality in dentistry. Stem cells should be differentiated to the appropriate cell types before they can be used clinically, otherwise it might lead to deleterious effects. Future tissues like tissue engineered bone grafts, engineered joints and cranial sutures can be developed with stem cell therapy. A team of professionals including stem cell biologists, molecular biologists, geneticists and clinicians with knowledge of oral and maxillofacial disorders is needed to develop the field of craniofacial tissue engineering.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Buccal fat pad: A location for obtaining adipose divide stem cells

Background  Buccal fat pad is known as anatomic structure in between the masticatory muscles that separate these muscles from each other and surrounding bone. Ease of access, through the intraoral route makes it suitable choice for obtaining adipose derived stem cells. Methods  Intraoral incisions for getting access to the buccal fat of pad are; Retromolar incision, incision in medial of pt...

متن کامل

The Cancer Stem Cell Hypothesis in Oral Squamous Cell Carcinoma: A New Target for the Treatment

Within a single tumor clone, cells have significantly different abilities to proliferate and form new tumors. This has led to the hypothesis that most cells in a cancer have a limited ability to divide and only a small subset of distinct cells, the cancer stem cells (CSCs), has the capacity to self-renew and form new tumors . It has been proposed that the development of tumors is based exclusiv...

متن کامل

In vitro assessment of alendronate toxic and apoptotic effects on human dental pulp stem cells

Objective(s): Osteonecrosis of the jaw, as an exposed necrotic bone in the oral cavity, is one of the adverse effects of bisphosphonates, which have an affinity for bone minerals. This study investigates the cytotoxic effects of alendronate (ALN) as a nitrogen-containing bisphosphonate, on human dental pulp stem cells (hDPSCs). Materials and Methods: The mesenchymal stem cells (MSCs), obtained ...

متن کامل

A Schwannoma of the Soft Palate in a Child: Histological and Immunohistochemical Features and Surgical Method

Introduction: Schwannoma, or neurilemmoma, is a benign neoplasm of Schwann cells that is extremely rare in the soft palate. Herein we present a case of a soft palate schwannoma presenting with an ulcerated surface and purplish colour in a 12 year-old girl. This report also introduces a successful surgical technique for coverage of the defect left by surgery.

متن کامل

Wisdom Tooth as the Source of Stem Cells

Background  Wisdom teeth are usually removed as a routine procedure for therapeutic or prophylactic reasons. Developing wisdom teeth are easy accessible source of stem cells during the adulthood which could be obtained. Methods  Search of the PubMed for stem cells and tooth was done. An inclusion criterion was extract of stem cells from wisdom tooth. Results  Stem cells can be obtained fro...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2016